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Health authorities in several countries around the world have launched an investigation into the effectiveness of the erectile dysfunction drug Cialis.

The online pharmacy chain, which sells the drug as Tadalafil, said it has launched a full-scale clinical investigation into the side effects of the drug.

According to the company, the product, which is sold under the brand name Cialis, was effective in 80% of men with erectile dysfunction and in 80% of these cases, it was linked to a dangerous side effect called "stomach upset".

"The safety profile of Cialis has been established through research carried out on healthy male volunteers in trials conducted on the drug's human volunteers, as well as on subjects with diabetes, high blood pressure and high cholesterol," the statement said.

It added that it was concerned about the "significantly higher incidence" of "severe side effects, particularly concerning the heart and kidneys".

The product works

A spokesman for the online pharmacy chain told The Sun the operation was launched in December last year and will be expanded in the coming months.

"We hope this investigation will help to provide additional information to physicians and patients about the safety and efficacy of Cialis in treating erectile dysfunction," the spokesman said.

The risks of taking Cialis

The erectile dysfunction drug, sold under the brand name Cialis, was originally developed to treat benign prostatic hyperplasia (BPH).

The drug was also used to treat pulmonary hypertension, which is a condition in which the walls of the arteries become enlarged.

The erectile dysfunction drug, which is sold under the brand name Tadalafil, was originally developed to treat erectile dysfunction in men.

It has now been established that it may have some adverse effects on men suffering from BPH.

The effects of Cialis

Cialis, which is sold under the brand name Tadalafil, has been found to be associated with a higher risk of developing erectile dysfunction in men.

It can cause erectile dysfunction in two ways.

One is if the erectile dysfunction drug is taken for more than four hours, up to 36 hours after which time it might be necessary to have sexual intercourse.

The other is if it is taken before or after meals, or for up to an hour after which time it might be necessary to have sexual intercourse.

Tadalafil side effects

In the case of Tadalafil, Cialis can cause side effects in some men, particularly in the face, such as headache and flushing.

In rare cases, Tadalafil could cause serious side effects, such as chest pain and irregular heartbeat.

Some people have also reported side effects such as headaches, indigestion and nasal congestion.

The company stressed that it had no information on the safety of the drug in clinical trials.

Tadalafil safety

According to the website of the erectile dysfunction drug's manufacturer, Bayer, the safety of the drug has not yet been established.

Bayer, however, said that it had tested the drug and received "very positive" reports of the symptoms in over 80% of men taking it.

"When we conduct further clinical studies, we will be able to confirm safety and efficacy of this product," the company said.

How to use the product

The manufacturer of the erectile dysfunction drug, Bayer, said that it was taking precautions to ensure that the product "works as intended".

It added that its men's health website has sections where patients can read the information and have a "picture of the product and how it functions".

For the treatment of erectile dysfunction, the company said that it is using the product to treat the symptoms of benign prostatic hyperplasia, which is an enlarged prostate.

Bayer, which was developing Tadalafil, added that it was also concerned about the "significantly higher incidence" of "severe side effects" concerning the heart and kidneys.

In the case of Tadalafil, the erectile dysfunction drug can cause side effects in some men, particularly in the face, such as headache and flushing.

One of the most common side effects is headache, with men reporting a slight increase in pressure in the head.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Aphrodin

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Cialis (tadalafil) can interact with certain foods and beverages, possibly altering its effectiveness or increasing the if taking tadalafil multiple times a day.

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